Cardiovascular disease and sudden cardiac death: between genetics and genomics
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چکیده
منابع مشابه
Cardiovascular disease and sudden cardiac death: between genetics and genomics.
In 1980, polymorphic variance in the human genomewasused to generate a first, physical map allowing monogenic traits to be traced to certain chromosomal regions. Due to the recognition of fragment length polymorphisms (microsatellite markers) with several different alleles at the same chromosomal locus, single nucleotide polymorphisms (SNP) became neglected in this instance for a long time. The...
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From the Section of Electrophysiology, Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA (R.D.); Division of Preventive Medicine and Cardiovascular Medicine, Center for Arrhythmia Prevention, Brigham and Women’s Hospital, Boston, MA (C.M.A.). Correspondence to Christine M. Albert, MD, MPH, Division of Preventive Medicine and Cardiovascular Medicine, Center for Ar...
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Sudden cardiac death (SCD) remains a public health problem of major magnitude. Contrary to earlier expectations, and despite decreased overall cardiac mortality, SCD rates appear to be rising in concert with escalating global prevalence of coronary disease and heart failure, the two major conditions predisposing to SCD. With the exception of the implantable defibrillator, there are few effectiv...
متن کاملGenetics of sudden cardiac death.
Sudden cardiac death occurs in a broad spectrum of cardiac pathologies and is an important cause of mortality in the general population. Genetic studies conducted during the past 20 years have markedly illuminated the genetic basis of the inherited cardiac disorders associated with sudden cardiac death. Here, we review the genetic basis of sudden cardiac death with a focus on the current knowle...
متن کاملGenetics of sudden death
Recent advances in molecular biology have advanced our understanding of the genetic substrate predisposing to sudden death, especially in monogenic disorders. Numerous ion channels along with membrane structural proteins have been extensively investigated for their role in the genesis of serious ventricular tachyarrhythmias. The complex interplay of various biological pathways culminating in th...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2015
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehv173